Enzymes Cofactors of Krebs Cycle

Enzyme

Cofactors

Inhibitors

DG(kcal/mol)

citrate synthase

-9.1

aconitase

fluorocitrate

+1.6

isocitrate dehydrogenase

NADP+

-1.7

a-ketoglutarate dehydrogenase

NAD+, FAD, lipoate

arsenite

-8.8

succinic thiokinase

ATP

hydroxylamine

-2.1

succinate dehydrogenase

FAD,

FeS group

malonate

0

fumarase

meso-tartrate

-0.9

malate dehydrogenase

NAD+

b-fluoroxalacetate fluoromalate

+6.7

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. . . since 10/06/06