Enzymes Function Krebs Cycle

Enzyme Function in Krebs cycle
pyruvate dehydrogenase pyruvate + NAD+ + CoASH → acetyl-CoA + NADH + CO2

Provides acetyl-CoA for entry to cycle

citrate synthase oxalacetate + acetyl–CoA → citrate + CoASH
aconitase citrate isocitrate
isocitrate dehydrogenase isocitrate + NAD+ → a-oxoglutarate NADH

isocitrate + NADP+ → a-oxoglutarate NADH

a-ketoglutarate dehydrogenase a-oxoglutarate + NAD+ + CoASH → succinyl-CoA + NADH + CO2
succinic thiokinase succinyl-CoA + GTP (or ATP) + CoASH → succinyl-CoA + PPi + GMP (or AMP)
succinate dehydrogenase succinate + FAD → fumarate + FADH2
fumarase fumarate + H2O → L-malate
malate dehydrogenase malate + NAD+ → oxalacetate + NADH + H+

malate + NADP+ → oxalacetate + NADPH + H+

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. . . since 10/06/06