Enzymes Function Krebs Cycle

Enzyme	Function in Krebs cycle
pyruvate dehydrogenase	pyruvate + NAD+ + CoASH → acetyl-CoA + NADH + CO2 Provides acetyl-CoA for entry to cycle
citrate synthase	oxalacetate + acetyl–CoA → citrate + CoASH
aconitase	citrate isocitrate
isocitrate dehydrogenase	isocitrate + NAD+ → a-oxoglutarate NADH isocitrate + NADP+ → a-oxoglutarate NADH
a-ketoglutarate dehydrogenase	a-oxoglutarate + NAD+ + CoASH → succinyl-CoA + NADH + CO2
succinic thiokinase	succinyl-CoA + GTP (or ATP) + CoASH → succinyl-CoA + PPi + GMP (or AMP)
succinate dehydrogenase	succinate + FAD → fumarate + FADH2
fumarase	fumarate + H2O → L-malate
malate dehydrogenase	malate + NAD+ → oxalacetate + NADH + H+ malate + NADP+ → oxalacetate + NADPH + H+