Complement Receptors

The complement system comprises an assembly of liver-manufactured, soluble and cell-bound proteins that participate in innate and adaptive immunity. Activation of the complement cascade by protease cleavage leads to chemotaxis (C5a), inflammation and increased capillary permeability (C3a, C5a), opsonization (C3b), and cytolysis.

 Fc receptors  Immune Cytokines  Immunoglobulins  Interferons

receptor ligands functions
CR1 (CD35) C3b, C3bi, C4b, C4bi opsonization and antigen clearance (phagocytes), antigen persistence (FDC), immune complex clearance (RBC), complement regulation
C1qR C1q immune complex binding to phagocytes(macrophages, neutrophils)
CR2 (CD21) C3d, C3dg, C3bi, EBV B cell activation ( B cells, FDC)
CR3 (MAC-1, CD11b/CD18) C3bi adhesion, extravasation, phagocytosis of macrophages and neutrophils
CR4 (p150.95, CD11c/CD18) C3bi adhesion, extravasation, phagocytosis of macrophages and neutrophils
C5aR C5a adherence, phagocytosis, CR1 and CR3 expression (macrophages, neutrophils)
C3aR, C4aR, C5aRC3a, C4a, C5a

granule release from mast cells, contraction of smooth muscle

 Fc receptors  Immune Cytokines  Immunoglobulins  Interferons

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. . . since 10/06/06